Sequence & Structure
Tirzepatide Sequence, Molecular Weight & Chemical Identity
3 min read•Published 2025-01-13•Quality Peptide USA Research
Tirzepatide is a synthetic 39-amino-acid peptide built as a dual agonist of the GIP and GLP-1 receptors. It is one of the most extensively characterized incretin-mimetic research peptides of the last decade, frequently used as a benchmark in comparative metabolic studies. This guide covers sequence & structure for Tirzepatide — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.
Primary Sequence
The primary sequence of Tirzepatide is recorded as: 39-residue GIP-based backbone with C20 fatty diacid conjugation. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.
Molecular Formula and Weight
Tirzepatide carries the molecular formula C225H348N48O68 and a calculated monoisotopic weight of approximately ≈ 4814 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.
Identifiers and Synonyms
CAS Registry: 2023788-19-2. Common synonyms include LY3298176, GIP/GLP-1 Dual Agonist. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.
Structural Notes for Researchers
Tirzepatide is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.
Research Use Only
All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.
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