Sequence & Structure
Tesamorelin Sequence, Molecular Weight & Chemical Identity
3 min read•Published 2025-11-23•Quality Peptide USA Research
Tesamorelin is a stabilized 44-amino-acid analog of growth hormone–releasing hormone (GHRH). A trans-3-hexenoic acid modification on the N-terminus protects it from rapid enzymatic degradation, giving it a notably longer research half-life than native GHRH(1-44). This guide covers sequence & structure for Tesamorelin — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.
Primary Sequence
The primary sequence of Tesamorelin is recorded as: Trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-... (44 residues). Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.
Molecular Formula and Weight
Tesamorelin carries the molecular formula C223H348N72O69S and a calculated monoisotopic weight of approximately ≈ 5135 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.
Identifiers and Synonyms
CAS Registry: 218949-48-5. Common synonyms include TH9507, Egrifta (research). When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.
Structural Notes for Researchers
Tesamorelin is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.
Research Use Only
All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.
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