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Sequence & Structure

Sermorelin Sequence, Molecular Weight & Chemical Identity

3 min read•Published 2025-09-06•Quality Peptide USA Research

Sermorelin is the synthetic 29-amino-acid N-terminal fragment of human GHRH (GHRH 1-29). This fragment retains the full intrinsic activity of the parent hormone at the GHRH receptor, making it a classic tool compound for somatotropic axis research. This guide covers sequence & structure for Sermorelin — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.

Primary Sequence

The primary sequence of Sermorelin is recorded as: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.

Molecular Formula and Weight

Sermorelin carries the molecular formula C149H246N44O42S and a calculated monoisotopic weight of approximately ≈ 3358 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.

Identifiers and Synonyms

CAS Registry: 86168-78-7. Common synonyms include GHRH(1-29), GRF(1-29)NH2. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.

Structural Notes for Researchers

Sermorelin is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.

Research Use Only

All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.

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