Sequence & Structure
Retatrutide Sequence, Molecular Weight & Chemical Identity
3 min read•Published 2025-03-03•Quality Peptide USA Research
Retatrutide is an investigational synthetic peptide engineered as a single-molecule triple agonist of the GLP-1, GIP, and glucagon receptors. Its design unites the metabolic signaling profiles of three native incretin and counter-regulatory hormones into one sequence, making it one of the most-studied multi-receptor research peptides in current metabolic literature. This guide covers sequence & structure for Retatrutide — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.
Primary Sequence
The primary sequence of Retatrutide is recorded as: Modified 39-residue peptide with C20 fatty acid conjugation. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.
Molecular Formula and Weight
Retatrutide carries the molecular formula C221H343N51O67 and a calculated monoisotopic weight of approximately ≈ 4731 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.
Identifiers and Synonyms
CAS Registry: not assigned in publicly indexed registries. Common synonyms include LY3437943, GLP-1/GIP/Glucagon Tri-Agonist. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.
Structural Notes for Researchers
Retatrutide is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.
Research Use Only
All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.
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