Sequence & Structure
PT-141 Sequence, Molecular Weight & Chemical Identity
3 min read•Published 2025-05-05•Quality Peptide USA Research
PT-141 (Bremelanotide) is a synthetic 7-amino-acid cyclic analog of α-MSH and a non-selective agonist of the melanocortin receptors, with notable activity at MC3R and MC4R. It is studied in research models of central nervous system signaling and melanocortin pharmacology.. This guide covers sequence & structure for PT-141 — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.
Primary Sequence
The primary sequence of PT-141 is recorded as: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.
Molecular Formula and Weight
PT-141 carries the molecular formula C50H68N14O10 and a calculated monoisotopic weight of approximately ≈ 1025.18 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.
Identifiers and Synonyms
CAS Registry: 189691-06-3. Common synonyms include Bremelanotide. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.
Structural Notes for Researchers
PT-141 is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.
Research Use Only
All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.
PT-141PT-141 researchPT-141 sequence & structurePT-141 for salebuy PT-141PT-141 US synthesizedPT-141 American peptidesPT-141 certificate of analysisresearch peptidesQuality Peptide USA