Sequence & Structure
GHK-Cu Sequence, Molecular Weight & Chemical Identity
3 min read•Published 2025-09-12•Quality Peptide USA Research
GHK-Cu is a naturally occurring copper-binding tripeptide complex (Glycyl-L-Histidyl-L-Lysine bound to Cu²⁺). It is one of the most well-characterized peptides in dermal and matrix-remodeling research, with decades of published in-vitro literature on collagen synthesis, antioxidant gene expression, and skin barrier dynamics.. This guide covers sequence & structure for GHK-Cu — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.
Primary Sequence
The primary sequence of GHK-Cu is recorded as: Gly-His-Lys + Cu²⁺. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.
Molecular Formula and Weight
GHK-Cu carries the molecular formula C14H24N6O4·Cu and a calculated monoisotopic weight of approximately ≈ 402.92 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.
Identifiers and Synonyms
CAS Registry: 89030-95-5. Common synonyms include Copper Peptide GHK, Prezatide Copper Acetate. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.
Structural Notes for Researchers
GHK-Cu is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.
Research Use Only
All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.
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